INSUBCONTINENT EXCLUSIVE:
Image copyrightAFPImage caption
Prof He says there is a potential second pregnancy
China has halted the
work of the scientist who claims to have created the world's first genetically edited babies, and says it will investigate.He Jiankui
caused outrage earlier this week when he told a genome summit he had altered the genes of twin baby girls so they could not contract HIV.His
statement has not been confirmed, but if true breaks tight rules around the use of gene editing in humans.Prof He's university said it was
unaware of his experiment.The Southern University of Science and Technology in Shenzhen said earlier in the week he had been on unpaid leave
since February, and it would be investigating the claims.On Thursday, China's science ministry said it had "demanded that the relevant
organisation suspend the scientific activities of relevant personnel".The National Health Commission has already said Prof He's work
"seriously violates China's laws, regulations and ethical standards" and would investigate the claims.What the scientist claimedProf He
announced that he had altered the DNA of embryos - twin girls known as Lulu and Nana - to prevent them from contracting HIV.Speaking to the
Human Genome Editing Summit at the University of Hong Kong, he said the girls were "born normal and healthy" and they would be monitored
over the next 18 years.He said he had funded the experiment himself and confirmed his university had not been aware of it.Prof He also
explained that eight couples - comprised of HIV-positive fathers and HIV-negative mothers - had signed up voluntarily for the experiment
One couple dropped out, but there was "another potential pregnancy" of a gene-edited embryo in its early stages
He said his study had been submitted to a scientific journal for review, though he did not name the journal
He was also evasive about other details, including the names of "some experts" he said had reviewed his work and offered feedback.Why is his
work controversialThe Crispr gene editing tool he claims to have used is not new to the scientific world, and was first discovered in
2012.Image:Fergus Walsh: "CRISPR gene editing
uses molecular scissors to cut both strands of DNAIt works by using "molecular scissors" to alter a very specific strand of DNA - either
cutting it out, replacing it or tweaking it.Gene editing could potentially help avoid heritable diseases by deleting or changing troublesome
coding in embryos.But experts worry meddling with the genome of an embryo could cause harm not only to the individual but also future
generations that inherit these same changes.Hundreds of scientists, both in China and around the world, swiftly condemned his
claims.Professor Julian Savulescu, an ethics expert at the University of Oxford, said if true "this experiment is monstrous"."Gene editing
itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life,
including the development of cancer," he told the TheIndianSubcontinent
"This experiment exposes healthy normal children to risks of gene editing for no real necessary benefit."Many countries, including the UK,
have laws that prevent the use of genome editing in embryos for assisted reproduction in humans
Scientists can do gene editing research on discarded IVF embryos, as long as they are destroyed immediately afterwards and not used to make
a baby.China allows in-vitro human embryonic stem cell research for a maximum period of 14 days, China's Deputy Minister of Science and
Technology Xu Nanping clarified.
